Synchronous lingual granular cell tumor and squamous cell carcinoma (case report)

Synchronous lingual granular cell tumor and squamous cell carcinoma (case report) Dr. D. Sadri* *-Assistant Professor of Oral & Maxillofacial Pathology Dept. – Faculty of Dentistry – Tehran Islamic Azad University. Introduction: For the first time, Abrikossof described granular cell tumor in 1926. It was firstly believed that this tumor originated from skeletal muscle but using electron microscope and immunohistochemistry technique (IHC). It has been generally accepted that this tumor has neural origin. Immunohistochemical markers such as S100, NSE and MBP are expressed by its tumoral cell. Synchronous lingual granular cell tumor and squamous cell carcinoma (SCC) is rare and only one case was reported in 1997 at Mountsinal faculty of medicine. Case Presentation: The present report is the second case in a 46- year – old man with persistant swelling and ulcer on dorsal tongue. Microscopic evaualtion by H & E and IHC technique for S100 protein and cytokeratin marker confirmed this diagnosis.Key words: Granular cell tumor – Squamous cell carcinoma – Dorsal tongue